Glycol Ether PNB is also partially water soluble and the water solubility can be increased by adding low molecular weight alcohols or other propylene glycol ethers. Another name for it is “propane-1,2-diol,” which is sometimes used when listing it as a compound on ingredient labels. This substance ranges from B to C depending on concentration/usage. NACRES NA.23 PROPYLENE GLYCOL T-BUTYL ETHER is incompatible with acids, oxidizing agents, oxygen (prolonged contact), water and dehydrating agents. Alpha 2u-globulin nephropathy and carcinogenicity following exposure to decalin (decahydronaphthalene) in F344/N rats. KH Chemicals has a wide range of products and a large worldwide selling market. C&L Inventory . Dipropylene Glycol Butyl Ether is supplied as a product that is >98.5% pure. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Propylene glycol monobutyl ether, 1-Butoxy-2-propanol: Solvenon® DPnB: CAS: 29911-28-2 Dipropylene glycol monobutyl ether, Butoxy dipropanol (mixture of isomers) Solvenon® TPnB: CAS: 55934-93-5 Mixture of propylene glycol mono butyl ethers Alibaba.com offers 825 di propylene glycol butyl ether products. Propylene glycol mono--butyl ether is used as a solvent in all-purpose cleaners, inks, and nail polish lacquers. NIH Draft Tentative Amended Report: Dec 5-6, 2016. The kidney and the liver were targets of PGMBE toxicity in rats. used as a PENETRATION enhancer. Regul Toxicol Pharmacol. Glycols & Glycol Ethers FBC offers a wide variety of Gycols and Gycol Ethers commonly used in cleaner and paint formulations. • Ethylene glycol monomethyl ether (2-methoxyethanol, CH3OCH2CH2OH) Dipropylene Glycol Butyl Ether is manufactured by reacting Propylene Oxide with Butanol. Exposure to PGMBE also produced increases in hepatic tumors in male and female mice. Propylene Glycol N-Butyl Ether Definition. These solvents are widely used paints & coatings, industrial cleaners, and inks. These compounds are alkyl ethers which originate from either ethylene glycol (“E-series”) or propylene glycol (“P-series”). Linear Formula CH 3 (CH 2) 3 OC 3 H 6 OC 3 H 6 OH . USA.gov. PubMed:Concentration and determination of the propylene glycol butyl ether esters of 2,4-dichlorophenoxyacetic acid (PGBE 2,4-D) in air. Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, Glish GL, Tarran R. PLoS Biol. Glycols are rarely found in nature but the simple structure especially of propylene glycols (i.e. 1-Butoxy-2-propanol . PROPYLENE GLYCOL T-BUTYL ETHER is incompatible with acids, oxidizing agents, oxygen (prolonged contact), water and dehydrating agents. Now question is, what does 1,3-Propenediol metabolize to? In the liver, the incidences of hepatocellular adenomas occurred with a positive trend in male rats, and may have been related to PGMBE exposure. Propylene series glycol ethers are used in surface coatings, leather, pesticides, electrical, industrial cleaners, resins, and printing inks; [ECETOC] Used as a coupling agent and solvent (degreasers, paint removers, metal cleaners, and hard surface cleaners), coalescent (latex coatings), coupling agent (water-based agricultural formulations), and chemical intermediate (epoxides, acid ester derivatives, … Propylene glycol tertiary ‐butyl ether (PGTBE) also has been tested and fails to cause these toxicities or birth defects in rats exposed by inhalation to substantial concentrations. Please enable it to take advantage of the complete set of features! Found in glass and all-purpose cleaners, DOWANOL™ PnB is a fast-evaporating glycol ether with an excellent balance of hydrophilic and hydrophobic character. : 5131-66-8 Formula : C7H16O2 Synonyms : 1-Butoxy-2-Propanol, Propylene Glycol (Mono) Butyl Ether, Propylene Glycol n-Butyl Ether; PNB 1.2. The PPG stands for propylene glycol. LyondellBasell produces the Arcosolv®* line of … Propylenglycolmonobutylether wird als Lösungsmittel und Insektenvertreibungsmittel verwendet.. Sicherheitshinweise. Products / Propylene Glycol Ethers Propylene Glycol n-Butyl Ether (PnB) Make an Enquiry Home; Products; Team; Partners; Contact ; General Terms & Conditions ; Rebain International (NL) B.V. Andries Copierhof 1A 3059 LM Rotterdam The Netherlands. Natl Toxicol Program Tech Rep Ser. Epub 2008 Oct 5. Propylene glycol mono-t-butyl ether (PGMBE) is used as a solvent in a variety of commercial applications. Propylene glycol (1, 2-propanediol) is an organic compound (a diol alcohol) and is a tasteless, odorless and colorless clear oily liquid. Evaluation of potential human carcinogenicity of the synthetic monomer ethyl acrylate. Dipropylene glycol dimethyl ether. Hooth MJ, Herbert RA, Haseman JK, Orzech DP, Johnson JD, Bucher JR. Toxicology. It is a mixture of four isomers. 2007 May;37(4):287-312. doi: 10.1080/10408440601177723. propylene glycol monobutylether . NLM NACRES NA.23  |  In the 2-year study, male rats displayed exposure-related nonneoplastic lesions in the kidney, and may have shown marginal increases in tubular neoplasms. In the 2-year study, the incidences of exposure-related hepatocellular adenoma, adenoma or carcinoma combined, and hepatoblastoma occurred with a positive trend, and were significantly increased in 1200 ppm groups. 2004 Nov 15;204(2-3):123-40. doi: 10.1016/j.tox.2004.06.019. alpha 2u-globulin nephropathy and renal tumors in national toxicology program studies. C&L Inventory . those who handle it must wear face masks, gloves and goggles. For example, propylene glycol ethyl ether (PGEE) and its acetate do not cause the critical toxicities of testicular, thymic, or blood injury and do not produce birth defects. commercially produced antiperspirants and e-cigarettes. UNII-59X1IJT82G. What’s so bad about PPG-14 butyl. No Data, Some Concern . Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies) Di(propylene glycol) butyl ether, mixture of isomers ≥98.5% Synonym: DOWANOL ® DPnB CAS Number 29911-28-2. Die Dämpfe von Propylenglycolmonobutylether können mit Luft ein explosionsfähiges Gemisch (Flammpunkt 59 °C, … No Data, Some Concern . HHS India Glycols is India’s largest glycol ether producer and the only plant in India to use a continuous process with world-renowned Sulzer Chemtech technology. MDL number MFCD01781688. We t studied the effects of propylene glycol mono-t-butyl ether on male and female rats and mice to identify potential toxic or cancer-related hazards to humans. (NTP, 1992). C&L Inventory . Linear Formula CH 3 (CH 2) 3 OC 3 H 6 OH . Propylene glycol has been used for over 50 years in a large variety of applications. The EPA requires This site needs JavaScript to work properly. Propylene Glycol Butyl Ether is the propylene glycol ether of n-butyl alcohol that conforms to the formula: C 7 H 16 O 2 It is used as a solvent and as a coalescent for water-borne latex coatings. 2018 Mar 27;16(3):e2003904. Ethoxydiglycol, the ethyl ether of diethylene glycol, contains only one hydroxyl group. Tripropylene glycol mono n-butyl ether. Molecular Weight 132.20 . Dipropylene Glycol Butyl Ether is manufactured by reacting Propylene Oxide with Butanol. In mice of both sexes, the major target of PGMBE toxicity was the liver. 59X1IJT82G. Renal lesions suggestive of alpha(2u)-globulin nephropathy were observed in male F344/N, in the 2 and 14-week studies, no kidney lesions were seen in NBR rats. It is used in a variety of coating, printing ink, and cleaning applications. DIPROPYLENE GLYCOL BUTYL ETHER . Continuing changes in E-series glycol ether products: In the major regions of the world, growth has been primarily for the butyl products (and some smaller-volume specialty glycol ethers); the methyl and ethyl products groups have been in decline. In the 2-week study, liver weights and in the 14-week study, liver weights and the incidences of centrilobular hypertrophy were increased. For example, propylene glycol ethyl ether (PGEE) and its acetate do not cause the critical toxicities of testicular, thymic, or blood injury and do not produce birth defects. The increased use of water-based surface coatings, in which glycol ethers play an important role, has led to the growth of the entire glycol market. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Other Applications: The properties listed in the previous section also support the use of Glycol Ether PNB in agriculture, cosmetics, electronics, ink, textile and adhesive products. Supplier CAS Number 1928-45-6 Synonym(s) Dow Weed Killer X; 2,4-D PGBE; Caswell No. tel. PubMed:Solid absorbent collection and gas chromatographic determination of the propylene glycol butyl ether esters of 2,4,5-T in air. Please contact us with questions or to… Verwendung. PnP Glycol Ether Propylene Glycol n-Propyl Ether NO 1.5 0.21 118/48 25.4 15.3 4.9 11.2 ∞ Applications Air fresheners and fragrances, cleaner formulations such as glass cleaners, hard surface cleaners, floor cleaners, rust removers, industrial cleaners, and metal cleaners DOWANOL™ TPnB Glycol Ether Tripropylene Glycol n-Butyl Ether As a pharmaceutical additive, propylene glycol is generally regarded as safe. Propylene Glycol Ethers (PGEs) are high performance solvents used in numerous industrial applications, including cleaners, inks, paints, and coatings. Propylene glycol tertiary‐butyl ether (PGTBE) also has been tested and fails to elicit these toxicities or birth defects in rats exposed by inhalation to substantial concentrations. 2018 Jul 1;198(1):67-76. doi: 10.1164/rccm.201710-2033OC. EC Number 225-878-4. Propylene Glycol can be found as food grade and is used in certain foods/supplements, it's metabolized into pyruvic acid, acetic acid, lactic acid and propionaldehyde. The EPA requires Propylene Glycol is. EC Number 249-951-5. Is hypersensitivity pneumonitis work-related? Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Propylene Glycol Butyl Ether is a propylene glycol ether of n-butyl alcohol. Propylene glycol mono-t-butyl ether (PGMBE) is used as a solvent in a variety of commercial applications. OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro.METHODS: Skin permeation was calculated using the Franz cell method with human skin. It is a mixture of four isomers. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Other uses and applications for PGEs include agricultural, cosmetic, electronic, ink, textile and adhesive products. +31 1045 08722 Email. We t studied the effects of propylene glycol mono-t-butyl ether on male and female rats and mice to identify potential toxic or cancer-related hazards to humans. Propylene glycol mono n-butyl ether . Registration dossier . Propylene Glycol n-Butyl Ether (PnB) CAS# 5131-66-8 Description Poly-Solv PnB - Propylene Glycol n-Butyl Ether is a clear, colorless liquid having a mild characteristic odor. It evaporates slowly and does not mix well with water. P-Series glycol ethers are propylene oxide-based, more hydrophobic, have lower surface tension and lower toxicity, and work well in higher pH systems. Belongs to the Following Reactive Group(s) 1,2- and more so 1,3-propanediol) makes it very likely (I have to admit, I do not know for certain but think that it actually is the case) that these do indeed occur as side products in trace amounts for example in natural microbial metabolism. Dipropylene Glycol Butyl Ether is the propylene oxide-based glycol ether. Ethyl tertiary-butyl ether: a toxicological review. 57018-52-7) in F344/N rats and B6C3F1 mice and a toxicology study of propylene glycol mono-t-butyl ether in male NBR rats (inhalation studies). Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. If you have any questions, comments, or concerns about the content of this page, please click here. PnP is commercially available as a mix of two isomers. Trade names . It is a component of cleaning formulations and of household and personal care products from which occupational and consumer exposure is likely. Propylenglycolmonobutylether ist eine farblose Flüssigkeit mit etherischem Geruch, die löslich in Wasser ist. PnP is a propylene oxide-based, or Pseries, glycol ether. It has low water solubility and good coupling and demonstrates good solvency for coating resins.  |  Dipropylene Glycol Butyl Ether is supplied as a product that is >98.5% pure. NTP technical report on the toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether (CAS No. May initiate the polymerization of isocyanates and epoxides. The Panel added Propylene Glycol Butyl Ether to the list of ingredients included in the RR. Belongs to the Following Reactive Group(s) (Mono) Propylene Glycol Normal Butyl Ether – is a colorless combustible liquid with an ether-like odor. About 2% of these are Alcohol & Hydroxybenzene & Ether. Occupational diseases associated with exposure to this agent: Industrial Processes with risk of exposure: Butoxypropanol; 1,2-Propylene glycol 1-monobutyl ether; 1-Butoxy-2-propanol; 2-Hydroxy-3-butoxypropane; Propasol solvent B; Propylene glycol monobutyl ether; n-Butoxy-2-propanol; n-Butoxypropanol; 1-Butoxypropan-2-ol; 2-Propanol, 1-butoxy-; [ChemIDplus] PnB; [Reference #1] Dowanol PNB glycol ether; [Dow Chemical MSDS] PGBE; [Glycol Ethers Online], Colorless liquid; [ICSC] Odor of ether; [Dow Chemical MSDS], Propylene series glycol ethers are used in surface coatings, leather, pesticides, electrical, industrial cleaners, resins, and printing inks; [ECETOC] Used as a coupling agent and solvent (degreasers, paint removers, metal cleaners, and hard surface cleaners), coalescent (latex coatings), coupling agent (water-based agricultural formulations), and chemical intermediate (epoxides, acid ester derivatives, solvents, and plasticizers); [Reference #1], Adverse effects in animal studies include adaptive liver changes and reversible CNS depression, but no hematological, genotoxic, or carcinogenic effects; [ToxPlanet: ECETOC] A skin and eye irritant; [ICSC] May cause moderate skin and eye irritation; May cause mild, reversible corneal injury; [Dow Chemical MSDS] See "Dipropylene glycol n-butyl ether.".
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